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Global SARS-CoV-2 Covid-19 Outbreak 2020

The outbreak and rapid spread of SARS-CoV-2 Covid-19 has had a dramatic impact worldwide as the virus is highly contagious and spreads by air, from contaminated surfaces and via personal contact. Data suggests that the infection rate is higher than that measured for SARS, another virulent coronavirus. SARS-CoV-2 Covid-19 has rapidly spread in recent weeks to over 200 countries.

Social distancing is a primary strategy being used to slow the progress of transmission and infection, but this approach is not viable in the healthcare setting, where healthcare workers and sick patients are at constant risk and in close proximity to infected people. For the healthcare setting, a solution is needed that can kill the aerosolized virus and also kill the virus on surfaces, so that the spread of the disease can be slowed and the burden on the healthcare system eased.

HGI Industries Inc., a company based in Boynton Beach, Florida, has developed a novel, patent protected technology that can kill coronavirus Covid-19 in both the air and on surfaces. HGI manufactures a range of innovative sanitizing devices (Odorox® line) that are powered by high energy ultraviolet photochemistry, replicating the cleaning action of the sun. These devices kill 99.99% of viruses, bacteria, mold and other pathogens in air, on surfaces and on fabrics safely, in areas as small as an office or as large as hundreds of thousands of square feet. Odorox's proprietary technology sanitizes by generating effective levels of atmospheric hydroxyls, nature’s powerful atmospheric sanitizing oxidant that is both safe for occupied spaces and effective in sanitizing.

Airborne hydroxyls are the perfect sanitizing agent. They react with a broader range of chemicals and are over one million times faster than ozone, bleach and other sanitizing agents. They react so fast that they are consumed within a few seconds, so they never accumulate. Atmospheric hydroxyls are continuously produced by the action of the sun’s ultraviolet energy on oxygen and water in our atmosphere. They keep air safe to breathe by decomposing natural and man-made pollutants and killing microorganisms. They sanitize air and surfaces by a natural process called lysing, where the hydroxyls react chemically with the lipids, protein carbohydrates and other organic chemicals in the cell wall and membranes of viruses, bacteria and other pathogens. The interior contents of the cells leak and the organism is destroyed. The mechanism for killing microorganisms is not biological, so the bacteria or viruses cannot develop any form of immunity.

Odorox® kill rates across a broad range of microorganisms on hard and porous surfaces and in air are consistently over 99.9%. Kill rates for aerosolized microorganisms are exceptionally high in the measured range of 99.99% to 99.999% in two hours, as shown below from a study of the Odorox® MDU/Rx™ device presented to the FDA. This is particularly effective for the spread of viral disease as an important vector for transmission is inhalation of aerosolized virus.

Testing a new, virulent virus like the coronavirus Covid-19 is not easy for several reasons. Only major national labs like the Centers for Disease Control and Prevention (CDC) and National Institutes of Health (NIH) get samples soon after the emergence of a new virus. Most commercial labs are not equipped to test virulent virus as it requires biosafety containment facilities and protocols beyond their capability (level 3 or 4). A proven alternative approach adopted by the FDA is to test recognized surrogate viruses in studies where they are aerosolized to mimic the most important transmission mode. HGI conducted such studies to demonstrate the expected efficacy of its technology in killing and reducing the propagation of Coronavirus.

At the Aerosol Research & Engineering Laboratories (ARE Labs), a laboratory specializing in the study of aerosolized microorganisms, HGI conducted an FDA approved evaluation of the kill rates of two representative bacteria, two representative viruses and a mold as part of the approval process for its MDU/RX portable device. All five kill rates were between 4 and 5 log reductions (99.99% and 99.999%) within two hours, an exceptionally high, fast kill rate.

The FDA selected the MS2 and Phi-X174 viruses for this study because they had different viral sheaths and were representative of the two main types of viruses. MS2 bacteriophage (ATCC 15597-B1) is positive-sense, single-stranded RNA virus that infects the bacterium Escherichia coli and other members of the Enterobacteriaceae family. MS2 is routinely used as a simulant for pathogenic RNA viruses such as the coronavirus Covid-19 Phi-X174 (ATCC 13706-B1) bacteriophage i s a circular single stranded DNA based virus that infects the bacterium Escherichia coli. Phi-X174 was selected as a simulant for DNA based pathogenic viruses.”

The kill rate profiles for these viruses are shown below. It is notable that the baselines remain very stable during the trial and the rates of viral decline are similar and rapid, and achieve the FDA minimum level of efficacy of 99% (2 log reduction) within 15 to 30 minutes.

MS2 - Reduction in viable concentration vs time

PhiX174 - Reduction in viable concentration vs time

Odorox leveraged these and other safety and efficacy results to obtain FDA approval for its Odorox® MDU-Rx device (FDA 510k #133800 approval as a medical device). The MDU-Rx is approved by the FDA for use in occupied spaces in medical facilities.

Odorox's UV technology is unique: it is completely different from germicidal UV-C technology. Odorox devices generate more intense and high energy UV radiation within a patented reflection chamber. Different models are customized for specific applications and volumes of space to ensure that hydroxyl levels match the safe levels found in nature.

OdoroxAir portable devices can treat rooms from 300 to 6,000 square feet, either as standalone units or by integrating them into existing heating and ventilation ducts. Odorox commercial devices are designed to treat large spaces – hundreds of thousands of square feet - and feature integrated, interactive process controls and sensors that measure and control the levels of sanitizing oxidants ensuring consistent, safe levels.

OdoroxAir can design and implement custom solutions that effectively treat schools, colleges, commercial office spaces, healthcare facilities , fitness facilities which are at risk of corona virus Covid-19 contamination and propagation. OdoroxAir can help authorities to rapidly put in place solutions that sanitize the air and surfaces in almost anyfacily immediately with portable units and longer term, with permanent HVAC installations. OdoroxAir solutions can also be used to sanitize used previously used personal protective equipment and extend the the life of your critical supplies.

Where can I buy Odorox Hydroxyl Processors? Contact an OdoroxAir consultant now and we will answer any questions and walk you through the process.

Benefits of Odorox Technology, Testimonials from our Customers

This is the most effective and profitable deodorization tool on the market. We’ve used ODOROX® systems on many different types of jobs and it works every time. The best part is being able to occupy the structure while it’s running. We now teach ODOROX® at our training facility

Jeff Dornberg

A Tool to Keep You Healthy
Health And Safety
JEMS, Journal of Emergency Medical Services
Hydroxyl generators kill germs & snuff odors


An Odorox® .Slimline. model portable hydroxyl generator sanitizes this ambulance. Photo Thom Dick
FEATURED IN HEALTH AND SAFETY
We've talked about cooties before, Life-Saver. Nothing is scarier than some of the stuff you can't even see.
Fortunately, our bodies came equipped with an incredible array of weapons to protect us from sick people's diseases.

I can't find any studies that say so, but I don't think EMS providers get sick as often as most other people. If that's true, I suspect it's because we're exposed to so much disease on a regular basis that we're somewhat immune to it. I've always been impressed by that (and have always been grateful for it.) But I still think we'd be a lot safer if somebody could devise a surefire way to sanitize an ambulance without taking it apart.
In the March 2005 installment of this column, I discussed numerous ways EMS providers could minimize their exposure to disease. I suggested everything from leaving their boots at work to routinely cleaning door handles, stretchers, ceiling hardware and radio mics with contact cleaner. I've also talked about such practices as hand-washing, ditching exam gloves before driving, removing the floor hardware to address substances that accumulate there and not eating in ambulances.
I do brag some about my agency's crews. I hope you understand I love 'em to death. If you ever come and ride with us, you'll see why in about a second. Not only are they fine caregivers, but they also have hearts the size of toasters. If we were to lose just one of them, all of EMS would be damaged. Their families expect us to keep them safe, and we try hard to do that.
One of our first responders is an EMT named Chris Forbes. Chris is a lieutenant with our fire department here in Brighton, Colo., and he's a part-time distributor of gizmos called hydroxyl generators. Hydroxyl ions are unstable, negatively charged molecules that oxidize single-celled organisms, and thereby, destroy them. Chris showed us a device the size of a briefcase that's designed to produce and circulate hydroxyls throughout a closed environment about the size of a small house (2,000 square feet). We bought it (for about $2,800). When we take an ambulance out of service for maintenance, and before we give it back to a crew, we plug the device into the unit's 110VAC shoreline circuit and run it in the patient compartment for 24 hours with all the doors and windows closed.

We're pretty small-time, and we serve a poor district, so we don't have a lot of money for science. We've found no reference to anybody using hydroxyl generators in ambulances. But the independent lab reports we've read say that in structures, this device destroys more than 99.9% of airborne, surface and contained anthrax, Clostridium difficile, Escherichia coli, influenza A, Pseudomonas aeruginosa, Listeria monocytogenes, MRSA, Staph aureus, molds and their spores, and tuberculosis bacilli on stainless steel and cotton fabric surfaces during a single 12-hour exposure.(1?3)
We also know from experience that it eliminates biologic and non-biologic odors?including emesis, blood, smoke and ethanol?and produces no odors of its own.
They're commonly installed in the heating, ventilating and air conditioning systems of public buildings, especially in humid areas, and they're routinely used to purify structures after flooding. Fire departments use them to sanitize turnout gear.
How do these things work? Ours contains a fan that draws .dirty. air through a multiple-wavelength ultraviolet chamber, then exhausts it as clean air?along with hydroxyl ions?back into the environment. Hydroxyls occur naturally in sunlight. Although they're deadly to one-celled organisms, they're harmless to people and animals. Likewise, tests prove they break down airborne aldehydes, ozone, carbon monoxide and volatile organic compounds.(4)
According to Chris, you can actually get these things in much smaller sizes, designed for permanent mounting in an ambulance, for about $500. That would spread the cost of one over the span of a lease, or the life of a vehicle. JEMS - Journal of Emergency Medical Services
References

JEMS is a Premier Media Partner of the International Association of Fire Chiefs.

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